HIV Cervical Cancer Prevention Research Program

Title: HIV-Cervical Cancer Prevention Research Program

Period: July 2008 to April 2011

Collaborators:  National AIDS Research Institute (NARI), Pune India, Vanderbilt University (VU), Nashville, Tennessee, USA and B.J. Medical College-Sassoon General Hospital, Pune

Sponsor: Vanderbilt University (VU), Nashville, Tennessee, USA and National AIDS Research Institute (NARI) - ICMR, Pune India

Investigator/s: Dr. S. S. Hirve and Dr. V. S. Padbidri

Rationale:
Greater numbers of HIV-infected women in India are accessing antiretroviral therapy and may live long enough for malignancies like cervical cancer to manifest. This proposal seeks to develop research infrastructure and capacity as well as conduct preliminary studies to assess the incidence and prevalence of high-grade cervical squamous intraepithelial lesions and invasive cervical cancer among HIV-infected women in India. The NARI-Vanderbilt University consortium will seek to strengthen and sustain research capacity among four partner Indian institutions in Pune, Vadu, Belgaum and Namakkal, thereby covering three of the four peninsular states with high-HIV prevalence and improving generalizability. The proposed work will develop research capacity in the field of women’s health research in general and cervical cancer and HIV in particular. The overall goal is to contribute to the development of an evidence-base for healthcare policy making and designing screening programs for improving preventive health care for over two million HIV-infected women in India.

Aim/s and objectives:
To develop research capacity through development of clinical research infrastructure and community involvement plan for recruitment and retention of HIV-infected women in India.

The proposed site expansion was to achieve the following specific objectives:

  • Conducting a pilot feasibility study about the accuracy and acceptability of VIA and HPV testing as alternatives to cervical cytology for cervical cancer screening among HIV-infected women
  • Development of recruitment and retention strategies for enrolling and following-up HIV-infected women.

Research Methods/Study Design: Cross sectional study

Study population/ Sample size: 100 HIV positive women from Vadu Population

Feedback/Dissemination of results (in addition to publication), if any:
Through the HIV-Cervical Cancer preventive research program Shirdi Sai Rural Hospital of Vadu (Vadu Site) has developed a good clinical research infrastructure which would help for service provision to HIV infected population in Vadu area. The capacity of Vadu site is also strengthened to carry out such kind of clinical research in future. This program provided a good opportunity to Vadu to train their hospital, field and research staff for carrying out such studies in future and also to get state of art equipment like colposcope, LEEP machine etc. and thereby indicating achievement of one of the main objectives of the study. This program also provided platform to form a field network to do the follow up of HIV infected subjects in Vadu area and also beyond Vadu area

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