CSIR-TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) @ IGIB

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Rationale: In Ayurveda texts, though the principles of phenotypes in health and disease states are extremely well described, they are not readily decipherable and hence its potential has not been appreciated by modern genomic researchers. According to Ayurveda individual’s basic constitution (Prakriti) describes its predisposition and prognosis to disease status and also the treatment for disease and lifestyle regime. In Genomics, individual’s basic constitution is decided by its genetic makeup which indirectly reflects the levels of various biochemical parameters in individual which states its Health status. We aimed at establishment of high correlation of Prakriti with genomic signatures by isolating DNA, RNA and Plasma from the blood sample. It is anticipated that this approach of Ayurgenomics would allow development of surrogate methods for cost effective screening of predisposed individuals in the population. This would result in development of an integrative approach to systems biology for disease and health state.

Aim: To integrate Ayurveda into mainstream contemporary biology and to achieve global acceptability of the concepts and science of Ayurveda.

Objectives/Secondary Objectives:

  1. 1.To develop objective measures (anthropometric, skin types, autonomics nervous system, olfaction abilities, vital capacity etc) for Ayurveda concept based phenotypic (Prakriti) assessment.
  2. 2.To assess genome wide (expression, genetic, epigenetic and biochemical) differences in large number of individuals defined by specific Prakriti (Vata, Pitta Kapha) groups from a genetically homogeneous population
  3. 3.To study segregation of Prakriti phenotypes in family based studies and in older age group along with inheritance of Prakriti at genomic and molecular level.

Phase I-

IGIB/CSIR : Integration of Ayurveda with Genomics for systems biology approach in predictive and personalized medicine.

Duration: March 2009 to 2012

Phase II - Prakriti heritability and age effect study

Sponsor: Council of Scientific and Industrial Research, Anusandhan Bhawan, 2, Rafi Marg, New Delhi

MLP3601  CSIR (2009 – 2012); MLP901 – CSIR-TRISUTRA

Investigator (s):

  1. 1.Dr Mitali Mukerji (Principal Investigator), Programme Director CSIR-TRISUTRA and Senior Principal Scientist, Institute of Genomics and Integrative Biology, Delhi
  2. 2.Dr Bhavana Prasher (Principal Investigator), Senior Scientist and Head Ayurveda (CSIR-TRISUTRA), Institute of Genomics and Integrative Biology, Delhi
  3. 3.Dr Sanjay Juvekar (Co Investigator), Vadu Rural Health Program, KEM Hospital Research Centre, Pune.
  4. 4.Dr Binuja Varma (Co Investigator) Project Scientist CSIR-TRISUTRA at Institute of Genomics and Integrative Biology, Delhi

Broad Objective of CSIR-TRISUTRA @IGIB

  1. 1.To conduct research aimed at validation and providing scientific evidence to principles/concepts described in Ayurveda for predictive, personalized and pre-emptive approach to health and diseased conditions
  2. 2.To undertake and co- ordinate translational research for developing affordable health care solutions for diseases of national priority based on Ayurveda literature.
  3. 3.Development of affordable healthcare solutions based on Ayurveda, modern genomics and modern medicine knowledge..
  4. 4.To develop interdisciplinary human resources.

Methodology and Study population

10,000 individuals of equal number of healthy males and females between age groups of 18–40 years are residing in 22 villages of VRHP area were screened for identification of prospective subjects of predominant Prakriti in Phase 1

Recruitment of potential 528 individuals of predominant for detailed objective phenotyping as well as molecular and genomic studies

Out of these 528 individuals, family members of identified 106 Predominant Prakriti individuals are being recruited in ongoing phase to study heritability of Prakriti

Anticipated Outcome: This study aims to integrate Ayurveda into mainstream contemporary biology and achieve global acceptability of the concepts and science of Ayurveda.

Anticipated Outcome of CSIR-TRISUTRA and KEMHRC collaborative initiative

  1. 1.A prospective Ayurgenomics cohort with clinical phenotyping and objective measures has been established at VADU. This is the first and unique resource of its kind.
  2. 2.Development of repository of samples repository for genomics and molecular studies
  3. 3..Molecular signatures/objective phenotyping parameters which help classify the Prakriti types in Western Indian population
  4. 4.Identification of predictive markers for disease predisposition.
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