Title: “Immunological Parameters of Indian Population”.

Sponsor and funder: Serum Institute of India Pvt. Ltd (SIIPL)

Objective: It was conducted at KEMHRC, Vadu. It has been reported that the frequency of circulating immune cells changes with aging in males and females, and it contributes to the health and survival of individuals. In the present study, we investigated the frequency of CD4, CD8, NK cells, and B cells and its effector function in the PBMC of different age groups in healthy Indian population from Vadu HDSS population. Using flow cytometry-based assays, we investigated the frequency of NK cells and their cytotoxic potential in the peripheral blood in healthy Indian individuals. Our results showed most of the individuals with age >50 years had a higher frequency of CD56+ NK cells, but their cytolytic activity was lower in these groups. There was a significant difference in the frequency of CD4+ T cells between the different age groups in the females, whereas the frequency of CD8+ T cells was significantly decreased with age between males and females. The frequency of IFN--producing CD4+ T cells was lower in the age group >50 years in males and females, whereas CD8+ T cells significant change in the IFN- production at different age groups in males and females. Age-stratified data for B cells, plasma cells, and plasmablast cells did not show any significant alteration, except lower frequency of IgG+CD19+B cells in the age group 51-60 years. Our data showed that aging affects mainly cellular immunity (CD4, CD8, and NK cells) but not much on circulating B cell immunity. The cause of alteration of immune response with aging in male and female is not fully understood and need further investigation. We received the funding from Yakult Honsha Co. Ltd, Japan to conduct the said study.

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