Title: “Nasopharyngeal Pneumococcal carriage and immunogenicity with reduced and alternate dose schedule of pneumococcal conjugate vaccine in infancy” is ongoing at KEMHRC, Vadu.

Objective: The objective of this study is to assess the effect of reduced and alternate dose schedules of PCV13 and PCV 10on vaccine-type nasopharyngeal carriage by examining nasopharyngeal swabs at different time intervals along with assessment of immune response to reduced and alternate dose schedules. As per WHO recommendations, India needs to introduce the pneumococcal conjugate vaccine (PCV) in its Universal immunization program (UIP), as it has an under-­five mortality rate of >50 deaths/1000 live births. As India has a large birth cohort, the currently recommended 3 dose PCV schedule would be expensive. A reduced dose schedule will help increase affordability for PCV introduction in UIP. The study results will lay foundation for a roadmap to undertake vaccine efficacy studies with modified dose schedule and comparing this with the standard dosing for non-­inferiority outcomes and will have implication not only for India but also for other resource constraint settings with substantial programmatic and economic benefits. This study is in collaboration with International Clinical Epidemiology Network (INCLEN) and the Bill and Melinda Gates Foundation (BMGF).


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