Title: “Surveillance of pertussis amongst hospitalised infants in India” is ongoing at KEM Hospital Research Centre, Pune.

Funder:Sanofi

Objective: The Objective of the study is to estimate the proportion of infants with laboratory confirmed pertussis among all hospitalized infants with clinical suspicion of pertussis and to estimate the economic burden of pertussis on the household. Pertussis (whooping cough) caused by Bordetella pertussis continues to be an important public health problem in developing as well as developed countries. In recent years, there has been resurgence in cases of pertussis in countries with high vaccination coverage. In India, During the year 1987, the reported incidence was about 163,000 cases which came down to 40,508 in 2010 and 39,091 in 2011 reflecting a decline of about 75%. However, large number of cases go undetected and many non-pertussis cases are clubbed under the head of “whooping cough.” This is a multi-centric hospital-based surveillance conducted among hospitalized infants (≤ 1 year) with clinical suspicion of pertussis based on Modified Cherry’s criteria. Such infants would be screened for presence of Bordetella pertussis and/or Bordetella parapertussis in the nasopharynx. Central committee from KEM Hospital Research Centre is coordinating the study amongst all study sites and KEM Hospital microbiology laboratory acts as central laboratory. Two nasopharyngeal samples are collected from each eligible infant. One nasopharyngeal sample is tested in the local laboratory for culture and second sample is sent to central laboratory for PCR testing. The study will look at the number and proportion of hospitalized infants with laboratory confirmed pertussis amongst the all infants with clinical suspicion of pertussis. This study is in collaboration with Sri Ramachandra Medical College, Chennai Christian Medical College, Ludhiana; Institute of Child Health, Kolkata.


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