Title: Covid-19 Sero-Surveillance Studies

A. Establishing sentinel sero-surveillance to monitor the trend of SARS-CoV-2 infection transmission in the general population in rural Western India

Funder: NIHR Global Health Unit in Respiratory Health (RESPIRE)

Sponsor: University of Edinburgh

Primary Objective: Estimate the seroprevalence of SARS-CoV-2 infection in a rural population in Pune district, Western India

Secondary Objectives: 1. Monitor the trend of SARS-CoV-2 transmission in a rural population in Pune district, Western India 
2. Determine the risk factors for SARS-CoV-2 infection 
3. To determine morbidity status and quality of life in individuals with SARS-CoV2 Seropositivity

Study area: Rural areas in Junnar and Ambegaon talukas in Pune district

Study design: We will conduct repeated cross-sectional surveys (based on WHO strategy for COVID-19 sero surveillance) within specified communities to estimate the seroprevalence, i.e., IgG antibodies level in the serum, and monitor the trend of SARS-CoV-2 transmission in five different rounds of sero-surveys conducted at baseline, 1,2,3, and 6 months. We will utilize a multi-stage cluster random sampling method in each of the survey rounds.

Status: Study will start in January 2020

B. Establish serial sero-surveillance to monitor the trend of SARS-CoV-2, Dengue and Chikungunya infection transmission in the general population, India

Funder: National Biopharma Mission (NBM), Biotechnology Industry Research Assistance Council (BIRAC), Government of India

Study Site: Vadu HDSS area

Primary Objective: .1. Estimate the sero-prevalence of SARS-CoV-2 infection in the general population
2. Estimate the 4-monthly incidence of SARS-CoV-2 infection based on serial sero- surveys
3. Estimate cumulative sero-conversion of SARS-CoV-2 infection over a one-year period
4. Estimate the seroprevalence and annual sero conversion of Dengue and Chikungunya in a sub-sample of the study

Secondary Objectives: 1. Monitor the trend of SARS-CoV-2 transmission in the general population
2. Determine the prevalence and incidence of SARS CoV2 sero-positivity among the members of the households with at least one seropositive individual (clustering of infection at the household level) Determine the risk factors for SARS-CoV-2 infection
3. Determine the duration of persistence of antibodies in individuals tested positive for SARS-CoV-2 infection

Study design: Prospective follow-up of a cohort of individuals within specified geographical locations. The key groups of activities entailed would be A. Serial serosurveys at 4 monthly intervals for SARS-CoV2 (Month 0,4,8,12) B. Serial serosurvey at the 12-month interval for Dengue and Chikungunya (months 0 & 12) in a subset of the sample C. Syndromic acute febrile illness/Influenza-like illness surveillance through fortnightly phone calls

Status: Study will start in January 2020


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